Spontaneous mutation rate in retinoblastoma.

doi:10.1136/jcp.43.6.496

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Article

Spontaneous mutation rate in retinoblastoma.

Journal of clinical pathology - 1 Jun 1990

Morris J A

Abstract excerpt

A novel approach was used to estimate the in vivo mutation rate of the retinoblastoma gene. A mathematical formula can be used to calculate the probability of neoplasia induced by one or more mutations in a population of dividing cells. This formula can then be applied to epidemiological data on...

Topics

Adult
Child
Eye Neoplasms
Humans
Mathematics
Mitosis
Models, Genetic
Mutation
Oncogenes
Retinoblastoma

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