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Article

Spontaneous mutation rate in retinoblastoma.

Journal of clinical pathology - 1 Jun 1990

Morris J A

Abstract excerpt

A novel approach was used to estimate the in vivo mutation rate of the retinoblastoma gene. A mathematical formula can be used to calculate the probability of neoplasia induced by one or more mutations in a population of dividing cells. This formula can then be applied to epidemiological data on hereditary and sporadic retinoblastoma. The analysis yields an estimate of the in vivo mutation rate of 8 x...

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Identifiers

PMID: 2380395
DOI: 10.1136/jcp.43.6.496
PMCID: PMC502505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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