Article
The two-stage mutation model in retinal hemangioblastoma.
Ophthalmic genetics - 1 Sept 1998
Chang J H, Spraul C W, Lynn M L, Drack A, Grossniklaus H E
Abstract excerpt
BACKGROUND: The two-stage mutation model involving successive inactivation of both alleles of a tumor suppressor gene was originally proposed by Knudson, who analyzed the age incidence curves for unilateral and bilateral retinoblastoma, and suggested that hereditary tumors arise by a single somatic event superimposed on a defective genetic background and sporadic tumors by a two-stage somatic process. In this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.