The two-stage mutation model in retinal hemangioblastoma.

doi:10.1076/opge.19.3.123.2185

Back to search

Article

The two-stage mutation model in retinal hemangioblastoma.

Ophthalmic genetics - 1 Sept 1998

Chang J H, Spraul C W, Lynn M L, Drack A, Grossniklaus H E

Abstract excerpt

BACKGROUND: The two-stage mutation model involving successive inactivation of both alleles of a tumor suppressor gene was originally proposed by Knudson, who analyzed the age incidence curves for unilateral and bilateral retinoblastoma, and suggested that hereditary tumors arise by a single somat...

Topics

Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Female
Hemangioblastoma
Humans
Male
Middle Aged
Mutation
Retinal Neoplasms
von Hippel-Lindau Disease

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.