A two-stage model for childhood acute lymphoblastic leukemia: application to hereditary and nonhereditary leukemogenesis.

doi:10.1016/s0025-5564(96)00136-8

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Article

A two-stage model for childhood acute lymphoblastic leukemia: application to hereditary and nonhereditary leukemogenesis.

Mathematical biosciences - 1 Jan 1997

Wheldon E G, Lindsay K A, Wheldon T E, Mao J H

Abstract excerpt

A differential equation model is developed to represent a two-stage mutational process leading to childhood acute lymphoblastic leukemia (ALL). Leukemogenesis is modeled as transformation of target stem cells that initially grow rapidly in the embryo but plateau and then decline in postnatal chil...

Topics

Aging
Child
Child, Preschool
Embryo, Mammalian
Female
Humans
Incidence
Male
Middle Aged
Models, Genetic
Models, Theoretical
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Sex Factors
Stochastic Processes

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