Article
Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease.
Gastroenterology - 1 Oct 2007
Di Sabatino Antonio, Pickard Karen M, Gordon John N, Salvati Virginia, Mazzarella Giuseppe, Beattie Robert M, Vossenkaemper Anna, Rovedatti Laura, Leakey Nicholas A B, Croft Nicholas M, Troncone Riccardo, Corazza Gino R, Stagg Andrew J, Monteleone Giovanni, MacDonald Thomas T
Abstract excerpt
BACKGROUND & AIMS: Dendritic cells (DCs) play a crucial role in immune responses by controlling the extent and type of T-cell response to antigen. Celiac disease is a condition in which T-cell immunity to gluten plays an important pathogenic role, yet information on DCs is scant. We examined mucosal DCs in celiac disease in terms of phenotype, activation/maturation state, cytokine production, and function....
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