Article
In vitro differentiation of human monocytes into dendritic cells by peptic-tryptic digest of gliadin is independent of genetic predisposition and the presence of celiac disease.
Journal of clinical immunology - 1 Jan 2009
Rakhimova Maryam, Esslinger Birgit, Schulze-Krebs Anja, Hahn Eckhart G, Schuppan Detlef, Dieterich Walburga
Abstract excerpt
INTRODUCTION: This study was done to further reveal the role of the innate immune system in celiac disease. METHODS: Dendritic cells were matured from venous blood of patients with active or treated celiac disease and DQ2-DQ8-positive or negative controls. Dendritic cells were treated with a peptic-tryptic digest of gliadin (500 microg/ml) and their activation was analyzed by fluorescent-activated cell sorting...
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