Article

T Cell Receptors for Antigen on Intraepitheial Cytolytic T Lymphocytes in Celiac Disease Engage Enterocyte HLA-E and HLA-B

2024-09-06

Abstract excerpt

We compared duodenal biopsies showing active celiac disease (CeD) to normal controls using single cell RNA sequencing, cyclic immunofluorescence, RNAScope and proximity ligation assays. There is increased infiltration of villous but not crypt epithelium T cells bearing either αβ or γδ T cell receptors (TCRs) in CeD. Both T cell subsets are activated cytotoxic T lymphocytes (CTLs) and surprisingly are the predomina...

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Identifiers and source

Literature Corpus work: 1ce46330-b3f7-57db-b7e9-342e845d5521
DOI: 10.1101/2024.09.03.610908

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