Article
A transgenic model to study the pathogenesis of somatic mtDNA mutation accumulation in beta-cells.
Diabetes, obesity & metabolism - 1 Nov 2007
Bensch K G, Degraaf W, Hansen P A, Zassenhaus H P, Corbett J A
Abstract excerpt
Low levels of somatic mutations accumulate in mitochondrial DNA (mtDNA) as we age; however, the pathogenic nature of these mutations is unknown. In contrast, mutational loads of >30% of mtDNA are associated with electron transport chain defects that result in mitochondrial diseases such as mitochondrial encephalopathy lactic acidosis and stroke-like episodes. Pancreatic beta-cells may be extremely sensitive to...
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