Article

Diabetic conditions induce intolerance to accumulation of pathogenic mitochondrial DNAs

2019-10-02

Abstract excerpt

Marked accumulation of mitochondrial DNA (mtDNA) with a particular pathogenic mutation is necessary for the mutant mtDNA to express its pathogenicity as mitochondrial respiration defects. However, the nuclear genome background, or the physiological status, or both, might also be important for the pathogenic regulation of mutant mtDNAs, because most mitochondrial function is controlled by polypeptides encoded in th...

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Literature Corpus work: 32c92f08-d947-5685-b66a-43f5aa32eed2
DOI: 10.1101/790956

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