Article
Dynamics of drug-resistant HIV-1 in plasma and peripheral blood cells in patients during and after enfuvirtide therapy.
AIDS research and human retroviruses - 1 Sept 2007
Poveda Eva, Briz Veronica, Paraskevis Dimitrios, Barreiro Pablo, Hatzakis Angelos, Soriano Vincent
Abstract excerpt
Genetic analysis of HIV-1 gp41 in plasma and peripheral blood mononuclear cell (PBMC) compartments was performed longitudinally in 10 HIV-infected patients treated with enfuvirtide. The appearance of enfuvirtide resistance mutations in PBMCs (DNA) generally occurred after (from 23 to 157 weeks) being recognizable in plasma (RNA). The disappearance of drug-resistant HIV-1 mutations to enfuvirtide in seven patients...
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