Article
Specific mutations in HIV-1 gp41 are associated with immunological success in HIV-1-infected patients receiving enfuvirtide treatment.
The Journal of antimicrobial chemotherapy - 1 Oct 2006
Aquaro Stefano, D'Arrigo Roberta, Svicher Valentina, Perri Giovanni Di, Caputo Sergio Lo, Visco-Comandini Ubaldo, Santoro Mario, Bertoli Ada, Mazzotta Francesco, Bonora Stefano, Tozzi Valerio, Bellagamba Rita, Zaccarelli Mauro, Narciso Pasquale, Antinori Andrea, Perno Carlo Federico
Abstract excerpt
OBJECTIVES: To investigate gp41 variability and correlation with viro-immunological parameters in 54 HIV-1-infected patients receiving enfuvirtide added as single active drug to a failing regimen. METHODS: One hundred and two HIV-1 gp41 sequences and clinical follow-up from 54 enfuvirtide-treated patients were analysed from baseline to week 36 of treatment. The association of mutations with viraemia/CD4 count was...
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