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Article

Viral dynamics and in vivo fitness of HIV-1 in the presence and absence of enfuvirtide.

Journal of acquired immune deficiency syndromes (1999) - 15 Aug 2008

Marconi Vincent, Bonhoeffer Sebastian, Paredes Roger, Lu Jing, Hoh Rebecca, Martin Jeffery N, Deeks Steven G, Kuritzkes Daniel R

Abstract excerpt

OBJECTIVES: To estimate the in vivo fitness cost of enfuvirtide (ENF) resistance, we analyzed dynamic shifts in the HIV-1 quasispecies under changing selective pressure in 3 subjects on failing ENF-based regimens who interrupted ENF while maintaining stable background regimens. Subsequently, ENF was readministered for 4 weeks as "pulse intensification." METHODS: The proportion of plasma virus carrying the V38A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18645515
DOI: 10.1097/QAI.0b013e31817bbc4e
PMCID: PMC2709806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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