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Article

In vivo selection by enfuvirtide of HIV type-1 env quasispecies with optimal potential for phenotypic expression of HR1 mutations.

Antiviral therapy - 1 Jan 2009

Goubard Armelle, Clavel François, Mammano Fabrizio, Labrosse Béatrice

Abstract excerpt

BACKGROUND: HIV type-1 (HIV-1) resistance to enfuvirtide (ENF) is mediated by mutations in the HR1 domain of gp41. We have previously shown that some of these mutations are selected in the context of env backgrounds that are not dominant before exposure to ENF, suggesting that particular env environments could facilitate phenotypic expression of HR1-mediated ENF resistance. METHODS: Envelope clones, representing...

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Share to Drug Resistance, Viral
Share to Enfuvirtide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

Share to HIV Envelope Protein gp41

Share to Peptide Fragments

Share to Protein Structure, Tertiary

Share to Recombination, Genetic

Source

Identifiers

PMID: 19578246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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