Association between specific enfuvirtide resistance mutations and CD4 cell response during enfuvirtide-based therapy.

Abstract excerpt

Analysis of CD4 cell responses during 48 weeks of enfuvirtide therapy after virological failure (analysis of covariance) demonstrated significant associations between V38 mutations (n = 58 subjects) and continued CD4 cell increases and between Q40 mutations (n = 8) and loss of CD4 cell benefit (+34 versus -95 cells/mul, P < 0.001). Subjects with N43 (n = 20) or other mutations (n = 48) had intermediate CD4 cell...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CD4 Lymphocyte Count
• Share to CD4-Positive T-Lymphocytes