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Article

The Role of Historical Bioactivity Data in the Deconvolution of Phenotypic Screens.

Journal of biomolecular screening - 1 Jun 2014

Bornot Aurelie, Blackett Carolyn, Engkvist Ola, Murray Clare, Bendtsen Claus

Abstract excerpt

A substantial challenge in phenotypic drug discovery is the identification of the molecular targets that govern a phenotypic response of interest. Several experimental strategies are available for this, the so-called target deconvolution process. Most of these approaches exploit the affinity between a small-molecule compound and its putative targets or use large-scale genetic manipulations and profiling. Each of...

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PMID: 24441646
DOI: 10.1177/1087057113518966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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