Article
A signalome screening approach in the autoinflammatory disease TNF receptor associated periodic syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing.
Pharmacological research - 1 Nov 2017
Todd Ian, Negm Ola H, Reps Jenna, Radford Paul, Figueredo Grazziela, McDermott Elizabeth M, Drewe Elizabeth, Powell Richard J, Bainbridge Susan, Hamed Mohamed, Crouch Sharon, Garibaldi Jon, St-Gallay Steve, Fairclough Lucy C, Tighe Patrick J
Abstract excerpt
TNF receptor associated periodic syndrome (TRAPS) is an autoinflammatory disease caused by mutations in TNF Receptor 1 (TNFR1). Current therapies for TRAPS are limited and do not target the pro-inflammatory signalling pathways that are central to the disease mechanism. Our aim was to identify drugs for repurposing as anti-inflammatories based on their ability to down-regulate molecules associated with...
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