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Article

A systems biology approach to suppress TNF-induced proinflammatory gene expressions

7 Nov 2013

Abstract excerpt

BACKGROUND: Tumor necrosis factor (TNF) is a widely studied cytokine (ligand) that induces proinflammatory signaling and regulates myriad cellular processes. In major illnesses, such as rheumatoid arthritis and certain cancers, the expression of TNF is elevated. Despite much progress in the field, the targeted regulation of TNF response for therapeutic benefits remains suboptimal. Here, to effectively regulate...

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PMID: 24199619
DOI: 10.1186/1478-811x-11-84

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