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Molecular Heterogeneity in Glioblastoma: Potential Clinical Implications

3 Mar 2015

Abstract excerpt

Glioblastomas, (grade 4 astrocytomas), are aggressive primary brain tumors characterized by histopathological heterogeneity. High-resolution sequencing technologies have shown that these tumors also feature significant inter-tumoral molecular heterogeneity. Molecular subtyping of these tumors has revealed several predictive and prognostic biomarkers. However, intra-tumoral heterogeneity may undermine the use of...

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PMID: 25785247
DOI: 10.3389/fonc.2015.00055

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