Article
Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma
4 Mar 2016
Abstract excerpt
Heterogeneity is a hallmark of glioblastoma with intratumoral heterogeneity contributing to variability in responses and resistance to standard treatments. Promoter methylation status of the DNA repair enzyme O(6)-methylguanine DNA methyltransferase (MGMT) is the most important clinical biomarker in glioblastoma, predicting for therapeutic response. However, it does not always correlate with response. This may be...
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