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Article

Location, Location, Location

1 Oct 2007

Abstract excerpt

Neurons may be particularly sensitive to disruptions in transcription factor trafficking. Survival and injury signals must traverse dendrites or axons, in addition to soma, to affect nuclear transcriptional responses. Transcription factors exhibit continued nucleocytoplasmic shuttling; the predominant localization is regulated by binding to anchoring proteins that mask nuclear localization/export signals and/or...

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Identifiers

PMID: 17917581
DOI: 10.1097/nen.0b013e318156a3d7

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