Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Injury-induced HDAC5 nuclear export is essential for axon regeneration.

Cell - 7 Nov 2013

Cho Yongcheol, Sloutsky Roman, Naegle Kristen M, Cavalli Valeria

Abstract excerpt

Reactivation of a silent transcriptional program is a critical step in successful axon regeneration following injury. Yet how such a program is unlocked after injury remains largely unexplored. We found that axon injury in peripheral sensory neurons elicits a back-propagating calcium wave that invades the soma and causes nuclear export of HDAC5 in a PKCμ-dependent manner. Injury-induced HDAC5 nuclear export...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Axons
Share to Calcium Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylases

Share to Nerve Regeneration

Share to Sensory Receptor Cells

Share to Signal Transduction

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 24209626
DOI: 10.1016/j.cell.2013.10.004
PMCID: PMC3987749

Genes

HDAC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Injury-induced HDAC5 nuclear export is essential for axon regeneration.PMID 24209626Read ↗

Therapeutic opportunities and pitfalls in the treatment of axon degenerationSemantic proximity Read ↗

The role of neuritin 1 in synaptic plasticity and sensory nerve function: A potential therapeutic target for neuronal repairSemantic proximity Read ↗

PATZ1 Reinstates a Growth-Permissive Chromatin Landscape in Adult Corticospinal Neurons After InjurySemantic proximity Read ↗

Sarm1 Gates the Transition from Protective to Repair Schwann Cell States Following Nerve InjurySemantic proximity Read ↗

Integrin-driven Axon Regeneration in the Spinal Cord Activates a Distinctive CNS Regeneration ProgramSemantic proximity Read ↗

Inositol Polyphosphate-5-phosphatase K ( <i>Inpp5k</i> ) enhances sprouting of corticospinal tract axons after CNS traumaSemantic proximity Read ↗

Purified neuronal populations of regenerating retinal ganglion cells reveal DNA methylation-mediated role of Na+/K+-ATPase in axon regenerationSemantic proximity Read ↗

Transient receptor potential canonical 5 channels activate Ca2+/calmodulin kinase Igamma to promote axon formation in hippocampal neurons.Semantic proximity Read ↗

HDAC6 as a potential therapeutic target for peripheral nerve disordersSemantic proximity Read ↗

Histone methyltransferase Ezh2 coordinates mammalian axon regeneration via epigenetic regulation of key regenerative pathwaysSemantic proximity Read ↗

Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve RepairSemantic proximity Read ↗

Hyperactivated Stat3 boosts axon regeneration in the CNS.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.