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Article

Direct observation of importin α family member KPNA1 in axonal transport with or without a schizophrenia-related mutation.

The Journal of biological chemistry - 1 Apr 2025

Mizuno Katsutoshi, Sugahara Masaki, Kutomi Osamu, Kato Ryota, Itoh Takafumi, Fujita Satoshi, Yamada Masami

Abstract excerpt

Karyopherin α1 (KPNA1)/(human importin α5; mouse importin α1) facilitates cargo transport into the nucleus by forming a complex with a nuclear localization sequence containing cargo and importin β1 (IPOB1). The elevated KPNA1 expression in neurons and the correlation between mutations and psychiatric disorders suggest its broader significance beyond nucleocytoplasmic transport. Although KPNA1 is localized in the...

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Identifiers

PMID: 40010609
DOI: 10.1016/j.jbc.2025.108343
PMCID: PMC11982482

Genes

KPNA1
NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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