Article
Nucleolar sequestration of RelA (p65) regulates NF-kappaB-driven transcription and apoptosis.
Molecular and cellular biology - 1 Jul 2005
Stark Lesley A, Dunlop Malcolm G
Abstract excerpt
The molecular mechanisms that regulate nuclear NF-kappaB to determine whether the stimulation of this pathway has a pro- or anti-apoptotic effect on cells have yet to be fully defined. Nuclear compartmentalization is increasingly recognized as an important mechanism for regulating the activity of transcription-related proteins and modulating cell growth and death. We have investigated whether such...
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