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Article

The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways.

Nature communications - 3 Jul 2020

Zhang Sunyuan, Williamson Nicholas A, Duvick Lisa, Lee Alexander, Orr Harry T, Korlin-Downs Austin, Yang Praseuth, Mok Yee-Foong, Jans David A, Bogoyevitch Marie A

Abstract excerpt

The expanded polyglutamine (polyQ) tract form of ataxin-1 drives disease progression in spinocerebellar ataxia type 1 (SCA1). Although known to form distinctive intranuclear bodies, the cellular pathways and processes that polyQ-ataxin-1 influences remain poorly understood. Here we identify the direct and proximal partners constituting the interactome of ataxin-1[85Q] in Neuro-2a cells, pathways analyses...

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Identifiers

PMID: 32620905
DOI: 10.1038/s41467-020-17145-0
PMCID: PMC7334205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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