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RNA transport and localized protein synthesis in neurological disorders and neural repair

18 May 2007

Abstract excerpt

Neural cells are able to finely tune gene expression through post-transcriptional mechanisms. Localization of mRNAs to subcellular regions has been detected in neurons, oligodendrocytes, and astrocytes providing these domains with a locally renewable source of proteins. Protein synthesis in dendrites has most frequently been associated with synaptic plasticity, while axonally synthesized proteins appear to...

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PMID: 17514714
DOI: 10.1002/dneu.20511

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