Isolation and structure elucidation of thiazomycin- a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.

doi:10.1038/ja.2007.70

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Article

Isolation and structure elucidation of thiazomycin- a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.

The Journal of antibiotics - 1 Sept 2007

Jayasuriya Hiranthi, Herath Kithsiri, Ondeyka John G, Zhang Chaowei, Zink Deborah L, Brower Mark, Gailliot Francis P, Greene Joyce, Birdsall Gwyneth, Venugopal Jayashree, Ushio Misti, Burgess Bruce, Russotti Greg, Walker Andre, Hesse Michelle, Seeley Anna, Junker Beth, Connors Neal, Salazar Oscar, Genilloud Olga, Liu Kun, Masurekar Prakash, Barrett John F, Singh Sheo B

Abstract excerpt

Thiazolyl peptides are a class of rigid macrocyclic compounds richly populated with thiazole rings. They are highly potent antibiotics but none have been advanced to clinic due to poor aqueous solubility. Recent progress in this field prompted a reinvestigation leading to the isolation of a new thiazolyl peptide, thiazomycin, a congener of nocathiacins. Thiazomycin possesses an oxazolidine ring as part of the...

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PMID: 17917238
DOI: 10.1038/ja.2007.70

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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