Article
Antibacterial evaluations of thiazomycin- a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
The Journal of antibiotics - 1 Sept 2007
Singh Sheo B, Occi James, Jayasuriya Hiranthi, Herath Kithsiri, Motyl Mary, Dorso Karen, Gill Charles, Hickey Emily, Overbye Karen M, Barrett John F, Masurekar Prakash
Abstract excerpt
Thiazomycin is a novel thiazolyl peptide closely related to nocathiacin I. It was isolated from Amycolatopsis fastidiosa by chemical and biological screening. Thiazomycin showed highly potent bactericidal activity against Gram-positive pathogens (MIC range 0.002 approximately 0.064 microg/ml) and did not show cross-resistance to clinically relevant antibiotic classes such as beta-lactams, vancomycin,...
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