Gene encoded antimicrobial peptides, a template for the design of novel anti-mycobacterial drugs.

doi:10.4161/bbug.1.6.13642

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Article

Gene encoded antimicrobial peptides, a template for the design of novel anti-mycobacterial drugs.

Bioengineered bugs - 1 Jan 2000

Carroll James, Field Des, O'Connor Paula M, Cotter Paul D, Coffey Aidan, Hill Colin, Ross R Paul, O'Mahony Jim

Abstract excerpt

Nisin A is the most widely characterized lantibiotic investigated to date. It represents one of the many antimicrobial peptides which have been the focus of much interest as potential therapeutic agents. This has resulted in the search for novel lantibiotics and more commonly, the engineering of novel variants from existing peptides with a view to increasing their activity, stability and solubility.The aim of...

Topics

Anti-Bacterial Agents
Genetic Variation
Humans
Indicators and Reagents
Microbial Sensitivity Tests
Mycobacterium
Mycobacterium avium subsp. paratuberculosis
Mycobacterium tuberculosis
Nisin
Oxazines
Protein Engineering
Xanthenes

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Identifiers

PMID: 21468208
DOI: 10.4161/bbug.1.6.13642
PMCID: PMC3056091

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