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Discovery, synthesis, and optimization of teixobactin, a novel antibiotic without detectable bacterial resistance

25 May 2022

Abstract excerpt

Discovering new antibiotics with novel chemical scaffolds and antibacterial mechanisms presents a challenge for medicinal scientists worldwide as the ever-increasing bacterial resistance poses a serious threat to human health. A new cyclic peptide-based antibiotic termed teixobactin was discovered from a screen of uncultured soil bacteria through iChip technology in 2015. Teixobactin exhibits excellent...

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PMID: 35610021
DOI: 10.1002/psc.3428

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