Article

Discovery and biosynthesis of persiathiacins: Unusual polyglycosylated thiopeptides active against multi-drug resistant tuberculosis

2021-10-24

Abstract excerpt

Thiopeptides are ribosomally biosynthesized and post-translationally modified peptides (RiPPs) that potently inhibit the growth of Gram-positive bacteria by targeting multiple steps in protein biosynthesis. The poor pharmacological properties of thiopeptides, in particular their low aqueous solubility, has hindered their development into clinically useful antibiotics. Antimicrobial activity screens of a library of...

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Literature Corpus work: 5d72c34f-07db-5d3f-9a0f-cd14e00e7bcc
DOI: 10.1101/2021.10.24.465558

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