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Article

Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2.

Clinics (Sao Paulo, Brazil) - 1 Jan 2012

Wagner Simona M, Zhu ShuJun, Nicolescu Adrian C, Mulligan Lois M

Abstract excerpt

Multiple endocrine neoplasia type 2 is an inherited cancer syndrome characterized by tumors of thyroid and adrenal tissues. Germline mutations of the REarranged during Transfection (RET) proto-oncogene, leading to its unregulated activation, are the underlying cause of this disease. Multiple endocrine neoplasia type 2 has been a model in clinical cancer genetics, demonstrating how knowledge of the genetic basis...

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Source

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Identifiers

PMID: 22584710
DOI: 10.6061/clinics/2012(sup01)14
PMCID: PMC3328826

Genes

RET

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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