Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sirt1 modulates premature senescence-like phenotype in human endothelial cells.

Journal of molecular and cellular cardiology - 1 Nov 2007

Ota Hidetaka, Akishita Masahiro, Eto Masato, Iijima Katsuya, Kaneki Masao, Ouchi Yasuyoshi

Abstract excerpt

Yeast Sir2 plays critical roles in gene silencing, stress resistance and longevity. Mammalian Sirt1 NAD(+)-dependent protein deacetylase, the closest homolog of Sir2, regulates cell cycle, cellular senescence, apoptosis and metabolism, by functional interactions with a number of biological molecules such as p53. To investigate a role of Sirt1 in endothelial dysfunction and premature senescence, we examined the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Galactosidase
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium, Vascular

Share to Nitric Oxide Synthase

Share to RNA, Small Interfering

Share to Sirtuin 1

Share to Sirtuins

Share to Umbilical Veins

Source

Identifiers

PMID: 17916362
DOI: 10.1016/j.yjmcc.2007.08.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sirt1 modulates premature senescence-like phenotype in human endothelial cells.PMID 17916362Read ↗

SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescenceSemantic proximity Read ↗

SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and AtherosclerosisSemantic proximity Read ↗

Sirtuin 1 in Endothelial Dysfunction and Cardiovascular AgingSemantic proximity Read ↗

The Multifaceted Role of Endothelial Sirt1 in Vascular Aging: An UpdateSemantic proximity Read ↗

Emerging roles of SIRT1 in vascular endothelial homeostasisSemantic proximity Read ↗

Endothelial SIRT1 as a Target for the Prevention of Arterial Aging: Promises and ChallengesSemantic proximity Read ↗

SIRT1 Overexpression Maintains Cell Phenotype and Function of Endothelial Cells Derived from Induced Pluripotent Stem Cells.Semantic proximity Read ↗

SIRT3 protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway.Semantic proximity Read ↗

SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells.Semantic proximity Read ↗

H2O2 down-regulates SIRT7’s protective role of endothelial premature dysfunction via microRNA-335-5pSemantic proximity Read ↗

SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid FibroblastsSemantic proximity Read ↗

SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.