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Article

H2O2 down-regulates SIRT7’s protective role of endothelial premature dysfunction via microRNA-335-5p

4 Jan 2022

Abstract excerpt

Endothelial senescence is believed to constitute the initial pathogenesis of the atherosclerotic cardiovascular disease (ASCVD). MicroRNA-335-5p (miR-335-5p) expression is significantly up-regulated in oxidative stress-induced endothelial cells (ECs). Sirtuin7 (SIRT7) is considered to prevent EC senescence, yet data on its response to ASCVD risk factors are limited. The present study analyzed the elevated levels...

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PMID: 34981113
DOI: 10.1042/bsr20211775

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