Article
SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells.
Circulation research - 30 Apr 2010
Zu Yi, Liu Ling, Lee Mary Y K, Xu Cheng, Liang Yan, Man Ricky Y, Vanhoutte Paul M, Wang Yu
Abstract excerpt
RATIONALE: Endothelial senescence causes endothelial dysfunction, promotes atherogenesis and contributes to age-related vascular disorders. SIRT1 is a conserved NAD(+)-dependent deacetylase possessing beneficial effects against aging-related diseases, despite that the detailed functional mechanisms are largely uncharacterized. OBJECTIVE: The present study is designed to evaluate the protective effects of SIRT1 on...
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