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The Multifaceted Role of Endothelial Sirt1 in Vascular Aging: An Update

1 Sept 2024

Abstract excerpt

-dependent deacetylase sirtuin-1 (Sirt1) belongs to the sirtuins family, known to be longevity regulators, and exerts a key role in the prevention of vascular aging. By aging, the expression levels of Sirt1 decline with a severe impact on vascular function, such as the rise of endothelial dysfunction, which in turn promotes the development of cardiovascular diseases. In this context, the impact of Sirt1 activity...

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PMID: 39273039
DOI: 10.3390/cells13171469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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