Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emerging roles of SIRT1 in vascular endothelial homeostasis

15 Jul 2008

Abstract excerpt

Sir2 is a NAD(+)-dependent deacetylase, which regulates life span in multiple model organisms in response to caloric restriction. Mammalian homologues of Sir2 comprise a family of seven proteins termed sirtuins (SIRT1-SIRT7), which have gained considerable attention for their impact on several important physiological processes associated with metabolism and stress resistance. In addition, recent studies point to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Cardiovascular Disease and Adiposity
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18641460
DOI: 10.4161/cc.7.14.6267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emerging roles of SIRT1 in vascular endothelial homeostasisPMID 18641460Read ↗

The Multifaceted Role of Endothelial Sirt1 in Vascular Aging: An UpdateSemantic proximity Read ↗

Sirtuin 1 in Endothelial Dysfunction and Cardiovascular AgingSemantic proximity Read ↗

Endothelial SIRT1 as a Target for the Prevention of Arterial Aging: Promises and ChallengesSemantic proximity Read ↗

SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and AtherosclerosisSemantic proximity Read ↗

SIRT6 in Vascular Diseases, from Bench to BedsideSemantic proximity Read ↗

Sirtuins in vascular diseases: Emerging roles and therapeutic potentialSemantic proximity Read ↗

The enigmatic role of SIRT2 in the cardiovascular system: Deciphering its protective and detrimental actions to unlock new avenues for therapeutic interventionSemantic proximity Read ↗

Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype.Semantic proximity Read ↗

SIRT6 protects against endothelial dysfunction and atherosclerosis in miceSemantic proximity Read ↗

High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related ConditionsSemantic proximity Read ↗

The role of mammalian Sirtuin 6 in cardiovascular diseases and diabetes mellitusSemantic proximity Read ↗

SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease ProtectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.