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Article

Endothelial SIRT1 as a Target for the Prevention of Arterial Aging: Promises and Challenges

29 Nov 2021

Abstract excerpt

ABSTRACT: SIRT1, a member of the sirtuin family of longevity regulators, possesses potent activities preventing vascular aging. The expression and function of SIRT1 in endothelial cells are downregulated with age, in turn causing early vascular aging and predisposing various vascular abnormalities. Overexpression of SIRT1 in the vascular endothelium prevents aging-associated endothelial dysfunction and...

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PMID: 34840264
DOI: 10.1097/fjc.0000000000001154

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