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Article

SIRT3 protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway.

Life sciences - 1 Jan 2021

Chen Tongshuai, Ma Chang, Fan Guanqi, Liu Hui, Lin Xie, Li Jingyuan, Li Na, Wang Shujian, Zeng Mei, Zhang Yun, Bu Peili

Abstract excerpt

Hyperglycemia induces endothelial cells (ECs) dysfunction and vascular complications by accelerating ECs senescence. It also induces downregulation of sirtuins (SIRTs). However, the molecular mechanism involved in the regulation of ECs senescence by SIRT3 remains unclear. Here, we showed that high glucose (HG) decreased the expression level of SIRT3 in human umbilical vein endothelial cells (HUVECs), increased...

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Source

Identifiers

PMID: 33160987
DOI: 10.1016/j.lfs.2020.118724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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