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Sirtuin 1 in Endothelial Dysfunction and Cardiovascular Aging

6 Oct 2021

Abstract excerpt

Sirtuin 1 (SIRT1) is a histone deacetylase belonging to the family of Sirtuins, a class of nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic functions. SIRT1 localizes in the nucleus and cytoplasm, and is implicated in the regulation of cell survival in response to several stimuli, including metabolic ones. The expression of SIRT1 is associated with lifespan and is reduced with...

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PMID: 34690807
DOI: 10.3389/fphys.2021.733696

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