Article
Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly.
Traffic (Copenhagen, Denmark) - 1 Dec 2007
Zhao Xiang, Nothwehr Steven, Lara-Lemus Roberto, Zhang Bao-Yan, Peter Harald, Arvan Peter
Abstract excerpt
The retromer protein complex assists in recycling selected integral membrane proteins from endosomes to the trans Golgi network. One protein subcomplex (Vps35p, Vps26p and Vps29p) combines with a second (Vps17p and Vps5p) to form a coat involved in sorting and budding of endosomal vesicles. Yeast Vps35p (yVps35) exhibits similarity to human Vps35 (hVps35), especially in a completely conserved PRLYL motif...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Cell Nucleus
- Endosomes
- Genes, Dominant
- Insulin
- Membrane Proteins
- Microscopy, Fluorescence
- Models, Biological
- Molecular Sequence Data
- Mutation
- Phenotype
- Plasmids
- Proteasome Endopeptidase Complex