Article
Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases.
The Journal of cell biology - 1 May 1996
Cooper A A, Stevens T H
Abstract excerpt
VPS10 (Vacuolar Protein Sorting) encodes a large type I transmembrane protein (Vps10p), involved in the sorting of the soluble vacuolar hydrolase carboxypeptidase Y (CPY) to the Saccharomyces cerevisiae lysosome-like vacuole. Cells lacking Vps10p missorted greater than 90% CPY and 50% of another...
Topics
- Aspartic Acid Endopeptidases
- Carboxypeptidases
- Cathepsin A
- Cytosol
- Fungal Proteins
- Golgi Apparatus
- Hydrolysis
- Molecular Sequence Data
- Mutagenesis
- Phenotype
- Protein Binding
- Receptors, Cell Surface
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sequence Homology, Amino Acid
- Signal Transduction
- Tyrosine
- Vacuoles