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Article

Sorting of yeast membrane proteins into an endosome-to-Golgi pathway involves direct interaction of their cytosolic domains with Vps35p.

The Journal of cell biology - 16 Oct 2000

Nothwehr S F, Ha S A, Bruinsma P

Abstract excerpt

Resident late-Golgi membrane proteins in Saccharomyces cerevisiae are selectively retrieved from a prevacuolar-endosomal compartment, a process dependent on aromatic amino acid-based sorting determinants on their cytosolic domains. The formation of retrograde vesicles from the prevacuolar compartment and the selective recruitment of vesicular cargo are thought to be mediated by a peripheral membrane retromer...

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Identifiers

PMID: 11038177
DOI: 10.1083/jcb.151.2.297
PMCID: PMC2192648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Sorting of yeast membrane proteins into an endosome-to-Golgi pathway involves direct interaction of their cytosolic domains with Vps35p.PMID 11038177Read ↗

Distinct domains within Vps35p mediate the retrieval of two different cargo proteins from the yeast prevacuolar/endosomal compartment.Semantic proximity Read ↗

Retrograde traffic out of the yeast vacuole to the TGN occurs via the prevacuolar/endosomal compartment.Semantic proximity Read ↗

env1 Mutant of VPS35 gene exhibits unique protein localization and processing phenotype at Golgi and lysosomal vacuole in Saccharomyces cerevisiae.Semantic proximity Read ↗

Structural features of vps35p involved in interaction with other subunits of the retromer complex.Semantic proximity Read ↗

Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval.Semantic proximity Read ↗

Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.Semantic proximity Read ↗

Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly.Semantic proximity Read ↗

Arabidopsis VPS35, a retromer component, is required for vacuolar protein sorting and involved in plant growth and leaf senescence.Semantic proximity Read ↗

Vps10p transport from the trans-Golgi network to the endosome is mediated by clathrin-coated vesicles.Semantic proximity Read ↗

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.Semantic proximity Read ↗

Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex.Semantic proximity Read ↗

A novel immunodetection screen for vacuolar defects identifies a unique allele of VPS35 in S. cerevisiae.Semantic proximity Read ↗

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