Article
Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.
Journal of cell science - 15 Oct 2002
Burda Patricie, Padilla Steven M, Sarkar Srimonti, Emr Scott D
Abstract excerpt
A direct role for phosphoinositides in vesicular trafficking has been demonstrated by the identification of the yeast VPS34 gene encoding the phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate (PtdIns3P). Vps34p binds the protein kinase Vps15p, and it...
Topics
- Amino Acid Motifs
- Carboxypeptidases
- Carrier Proteins
- Cell Compartmentation
- Cytoplasm
- Endosomes
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Fungal
- Golgi Apparatus
- Membrane Proteins
- Mutagenesis, Site-Directed
- Phenotype
- Phosphatidylinositol 3-Kinases
- Phosphatidylinositol Phosphates
- Point Mutation
- Protein Binding
- Protein Serine-Threonine Kinases
- Protein Structure, Tertiary