Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice.

The EMBO journal - 31 Oct 2007

Herrmann Stefan, Stieber Juliane, Stöckl Georg, Hofmann Franz, Ludwig Andreas

Abstract excerpt

Cardiac pacemaking involves a variety of ion channels, but their relative importance is controversial and remains to be determined. Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, which underlie the I(f) current of sinoatrial cells, are thought to be key players in cardiac automaticity. In addition, the increase in heart rate following beta-adrenergic stimulation has been attributed to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP
Share to Cyclic Nucleotide-Gated Cation Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Rate

Share to Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

Share to Ion Channel Gating

Share to Ion Channels

Share to Isoproterenol

Share to Protein Isoforms

Source

Open in PubMed Open full text

Identifiers

PMID: 17914461
DOI: 10.1038/sj.emboj.7601868
PMCID: PMC2063478

Genes

HCN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice.PMID 17914461Read ↗

Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.Semantic proximity Read ↗

cAMP sensitivity of HCN pacemaker channels determines basal heart rate but is not critical for autonomic rate control.Semantic proximity Read ↗

Pacemaker activity of the human sinoatrial node: effects of HCN4 mutations on the hyperpolarization-activated current.Semantic proximity Read ↗

Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse ModelsSemantic proximity Read ↗

Updates on HCN Channels in the Heart: Function, Dysfunction and Pharmacology.Semantic proximity Read ↗

A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus TachycardiaSemantic proximity Read ↗

Differential contribution of HCN1 and HCN4 to the synchronisation of sinoatrial pacemaker cellsSemantic proximity Read ↗

HCN channels and heart rate.Semantic proximity Read ↗

Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current.Semantic proximity Read ↗

Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial node.Semantic proximity Read ↗

Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: insights into structure-function relationships and multimerization.Semantic proximity Read ↗

Pacemaker channels produce an instantaneous current.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.