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Article

Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Oct 2007

Zhang Yuan-Wei, Gesmonde Joan, Ramamoorthy Sammanda, Rudnick Gary

Abstract excerpt

Human serotonin transporter (hSERT) activity expressed in HeLa cells was stimulated by agents that release nitric oxide, stimulate soluble guanylyl cyclase, or activate cGMP-dependent protein kinase (PKG). This stimulation was blocked by a PKG inhibitor. A naturally occurring mutation, I425V, associated with obsessive-compulsive disorder and other neuropsychiatric disorders, activated hSERT and eliminated...

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Identifiers

PMID: 17913921
DOI: 10.1523/JNEUROSCI.0034-07.2007
PMCID: PMC6672823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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