Article
Glycosylation of a vesicular monoamine transporter: a mutation in a conserved proline residue affects the activity, glycosylation, and localization of the transporter.
Journal of neurochemistry - 1 Dec 1998
Yelin R, Steiner-Mordoch S, Aroeti B, Schuldiner S
Abstract excerpt
The role of N-glycosylation in the expression, ligand recognition, activity, and intracellular localization of a rat vesicular monoamine transporter (rVMAT1) was investigated. The glycosylation inhibitor tunicamycin induced a dose-dependent decrease in the rVMAT1-mediated uptake of [3H]serotonin....
Topics
- Amino Acid Substitution
- Animals
- Biological Transport
- CHO Cells
- Cell Line, Transformed
- Conserved Sequence
- Cricetinae
- Glycosylation
- Haplorhini
- Kinetics
- Ligands
- Membrane Glycoproteins
- Membrane Transport Proteins
- Mutation
- Neuropeptides
- Proline
- Rats
- Serotonin