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Article

Myristoylation of cGMP-dependent protein kinase dictates isoform specificity for serotonin transporter regulation.

The Journal of biological chemistry - 28 Jan 2011

Zhang Yuan-Wei, Rudnick Gary

Abstract excerpt

By transporting serotonin (5-HT) into neurons and other cells, serotonin transporter (SERT) modulates the action of 5-HT at cell surface receptors. SERT itself is modulated by several processes, including the cGMP signaling pathway. Activation of SERT by cGMP requires the cGMP-dependent protein kinase (PKG). Here we show that in HeLa cells lacking endogenous PKG, expression of PKGIα or PKGIβ was required for...

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Identifiers

PMID: 21097501
DOI: 10.1074/jbc.M110.203935
PMCID: PMC3024740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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