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Article

His452Tyr polymorphism in the human 5-HT2A receptor affects clozapine-induced signaling networks revealed by quantitative phosphoproteomics.

Biochemical pharmacology - 1 Mar 2021

Martín-Guerrero Sandra M, Alonso Paula, Iglesias Alba, Cimadevila Marta, Brea José, Loza M Isabel, Casado Pedro, Martín-Oliva David, Cutillas Pedro R, González-Maeso Javier, López-Giménez Juan F

Abstract excerpt

Antipsychotic drugs remain the current standard for schizophrenia treatment. Although they directly recognize the orthosteric binding site of numerous monoaminergic G protein-coupled receptors (GPCRs), these drugs, and particularly second-generation antipsychotics such as clozapine, all have in common a very high affinity for the serotonin 5-HT2A receptor (5-HT2AR). Using classical pharmacology and targeted...

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PMID: 33539816
DOI: 10.1016/j.bcp.2021.114440

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