Article
Motor and tail homology 1 (Th1) domains antagonistically control myosin-1 dynamics.
Biophysical journal - 4 Feb 2014
Mazerik Jessica N, Kraft Lewis J, Kenworthy Anne K, Tyska Matthew J
Abstract excerpt
Class 1 myosins are monomeric motor proteins that fulfill diverse functions at the membrane/cytoskeletal interface. All myosins-1 contain a motor domain, which binds actin, hydrolyzes ATP, and generates forces, and a TH1 domain, which interacts directly with membrane lipids. In most cases, TH1 is needed for proper subcellular localization and presumably function, although little is known about how this domain...
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