Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neutrophil-derived reactive oxygen species promote tumor colonization.

Communications biology - 13 Jul 2021

Zhong Jianghong, Li Qijing, Luo Huqiao, Holmdahl Rikard

Abstract excerpt

A single-nucleotide polymorphism of neutrophil cytosolic factor 1 (Ncf1), leading to an impaired generation of reactive oxygen species (ROS), is a causative genetic factor for autoimmune disease. To study a possible tumor protection effect by the Ncf1 mutation in a manner dependent on cell types, we used experimental mouse models of lung colonization assay by B16F10 melanoma cells. We observed fewer tumor foci in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Neoplastic
Share to Interleukin-1beta
Share to Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Mice, Transgenic

Share to NADPH Oxidases

Share to Neutrophils

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 34257370
DOI: 10.1038/s42003-021-02376-8
PMCID: PMC8277858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neutrophil-derived reactive oxygen species promote tumor colonization.PMID 34257370Read ↗

Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors.Semantic proximity Read ↗

Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice.Semantic proximity Read ↗

Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species.Semantic proximity Read ↗

Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.Semantic proximity Read ↗

Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.Semantic proximity Read ↗

Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in mice.Semantic proximity Read ↗

Methylcholanthrene-Induced Sarcomas Develop Independently from NOX2-Derived ROS.Semantic proximity Read ↗

Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.Semantic proximity Read ↗

Sequencing, expression, and functional analyses support the candidacy of Ncf2 in susceptibility to Salmonella typhimurium infection in wild-derived mice.Semantic proximity Read ↗

A Reduction in Intracellular Reactive Oxygen Species Due to a Mutation in NCF4 Promotes Autoimmune Arthritis in Mice.Semantic proximity Read ↗

A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus.Semantic proximity Read ↗

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.