Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration.

The Journal of clinical investigation - 1 Oct 2007

Chen Jing, Connor Kip M, Smith Lois E H

Abstract excerpt

Age-related macular degeneration (AMD), the most common cause of blindness in the elderly, is characterized by degeneration of the macula and can lead to loss of fine color vision. Alterations in inflammatory and immune system pathways, which arise from genetic differences, predispose individuals to AMD. Yet the mechanism of disease progression with respect to inflammation is not fully understood. In this issue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CX3C Chemokine Receptor 1
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Macular Degeneration

Share to Microglia

Share to Receptors, Chemokine

Share to Retina

Source

Open in PubMed Open full text

Identifiers

PMID: 17909623
DOI: 10.1172/JCI33513
PMCID: PMC1994636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration.PMID 17909623Read ↗

CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.Semantic proximity Read ↗

Microglial Cell Dysfunction in CRB1-Associated Retinopathies.Semantic proximity Read ↗

CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration.Semantic proximity Read ↗

CCR1 Signaling as a Common Injury Pathway in Retinal DegenerationSemantic proximity Read ↗

Microglia at Sites of Atrophy Restrict the Progression of Retinal Degeneration via Galectin-3 and Trem2 InteractionsSemantic proximity Read ↗

Infiltrating monocytes augment alternative complement activation and exacerbate inherited retinal degeneration in a mouse modelSemantic proximity Read ↗

Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration.Semantic proximity Read ↗

CD36 Deficiency Inhibits Retinal Inflammation and Retinal Degeneration in Cx3cr1 Knockout Mice.Semantic proximity Read ↗

Deciphering perivascular macrophages and microglia in the retinal ganglion cell layersSemantic proximity Read ↗

More than meets the eye: The role of microglia in healthy and diseased retinaSemantic proximity Read ↗

Deletion of Socs3 in LysM+ Cells and Cx3cr1 Resulted in Age-dependent Development of Retinal MicrogliopathySemantic proximity Read ↗

Synthesis and Propagation of Complement C3 by Microglia/Monocytes in the Aging RetinaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.